Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients

Authors

  • Alireza Irani Eye Resarch Center, Rassoul Akram Hospital, Tehran University of Medical Sceince, Tehran, Iran
  • Amin Reza Nikpoor Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Asaad Azarnejad Department of Medical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran
  • Hajar Aryan Fazeli-Sanati genetic laboratory, Tehran, Iran
  • Hamid Ghaedi Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hossein Nazari Eye Resarch Center, Rassoul Akram Hospital, Tehran University of Medical Sceince, Tehran, Iran
  • Javad Akhtari Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Khalil Ghasemi Falavarjani Eye Resarch Center, Rassoul Akram Hospital, Tehran University of Medical Sceince, Tehran, Iran
  • Mohammad Askari Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Hossein Sanati National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
Abstract:

Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in the sample population. Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and the control groups (P<0.05). The frequency of APOE&epsilon2 in patients was higher than controls (P = 0.00) and this variant allele showed a significant association with AMD even after removal of the effects of age, sex and smoking by logestic regression analysis (P = 0.00, OR= 3.439 CI 95% 1.664-7.108). On the other hand, the frequency distribution of APOE&epsilon4 was not statistically different between patients and healthy controls. Conclusion: The results show a moderate positive association between APOE &epsilon2 and AMD, but current data does not show any role for APOE &epsilon4 in protection from AMD. However, more studies are required to reveal the possible role of APOE in the pathogenesis of AMD.

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Journal title

volume 3  issue 2

pages  22- 27

publication date 2015-05

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